Showing posts with label Abuse. Show all posts
Showing posts with label Abuse. Show all posts

Sunday, July 9, 2017

The Sinclair Method VS Alcoholics Anonymous

I was searching for a topic today and I found the Sinclair method of approach to drinking too much alcohol. I think it is a good approach to the alternative of AA. You decide what you think. Here is a few words about what The Sinclair Method is:

The Sinclair Method (TSM) uses the nervous system’s own mechanism, called “extinction”, for gradually removing the interest in alcohol and the behaviors involved in alcohol drinking. Therefore, the technical term for TSM is “pharmacological extinction.”

The key scientific discovery underlying the treatment was that, contrary to earlier beliefs, detoxification and alcohol deprivation do not stop alcohol craving but in fact increase subsequent alcohol drinking[1],[2]. The old idea that alcoholism is caused by physiological dependence on alcohol, therefore, needed to be discarded, and a new understanding of alcoholism developed.

Subsequent research showed that alcohol drinking is a learned behavior [3]. Some individuals, partly for genetic reasons, get so much reinforcement each time they drink, and have so many opportunities to drink and get reinforcement, that the behavior becomes too strong. They cannot always control their drinking; they cannot “just say ‘no’.”  And society calls them alcoholics.
Laboratory studies indicated that in most cases, the reinforcement from alcohol involved the opioid system, i.e., the same system where morphine, heroin, and endorphin produce their effects.[4]

The brain has two primary mechanisms for changing its own wiring on the basis of experience.  First, there is learning for strengthening behaviors that provide reinforcement.  Second, there is extinction for removing behaviors that no longer produce reinforcement.  The best known example involves Pavlov’s dogs that learned to salivate to the sound of a bell when the bell was followed by food, but then had the learned behavior extinguished when the food reinforcement was no longer given after the bell was rung.

Certain medicines, such as naltrexone, naloxone and nalmefene, block the effects of endorphin and other opiates. I reasoned that if alcohol is drunk while one of these opioid antagonists is blocking endorphin reinforcement in the brain, the extinction mechanism would be activated, and it would then produce a small but permanent decrement in alcohol drinking and craving. The next day, the person would be slightly less interested in alcohol. Eventually control would be regained, and the person would no longer be an alcoholic; indeed, they no longer would be interested in alcohol[5].
The Sinclair Method was confirmed, first in a large body of laboratory studies[6], then in over 90 clinical trials around the world[7],[8],[9], and most recently in personal reports by people using it[10]. It has been found to be successful in about 80% of alcoholics.  This is very high for alcoholism treatment, but the treatment is not for everyone: some people apparently have a different form of alcoholism that does not involve the opioid system and cannot be treated effectively with opioid antagonists.

The Sinclair Method is simply taking an opioid antagonist before drinking. Naltrexone, naloxone, and nalmefene are not substitution drugs similar to methadone for heroin addiction or Nicorettes™ for nicotine addiction. The opioid antagonists are not addictive, and they do not directly reduce craving for alcohol.  And unlike disulfiram, the opioid antagonists do not produce an unpleasant aversive effect. Indeed, the opioid antagonists do not do anything until after endorphin has been released. Then the mechanism of extinction is triggered, and the extinction mechanism in turn progressively but permanently removes the neural cause for excessive drinking.John David Sinclair, Ph.D., Researcher Emeritus

Interesting study , as I have taken Naltraxone from my psychiatrist and I have to admit my craving for alcohol did not exist. I think it is good to look at alternative treatments. Please comment. Thank You Chris

Tuesday, March 28, 2017

Checked out Of Rehab

I checked out of Rehab for Xanax and Adderall on Monday as I could not go through this 30 day program. I got off all my medication but it was too fast of a withdrawal. My ears were ringing very bad in this loud facility and I went home because I needed something for my Panic which was over whelming to me, as a cloud of dust was a fog in my eyes. I went to my regular MD on Monday and he prescribed heart medication and Prozac for me to calm down and this has helped more than anything. I am finally off every pill except for 2 mg. of Xanax in which I put myself on compared to the 6 mg. I was taking for over 8 years. I do not drink anything alcoholic , so I am not at all concerned about any type of relapse, as this tr
eatment program was for alcoholics and drug users that have no experience with the 12 steps of AA. I have over eight years of sobriety and I took this medication as prescribed by a psychiatrist. Therefor I was ask many times why I was getting off Xanax, and I was told by two Doctors that I was taking too much. Inside , I kind of knew that 6 Mg. of Xanax was way too much , but i felt like the Dr. knew what he was talking about. Be careful about these Doctors that prescribe Xanax as it works very good with Panic attacks , but is very addictive in the long haul. I am feeling pretty good, going on a long walk with my puppy this early AM and I had breakfast and took the new medication with the blood pressure medication I have just gotten. I am taking this one day at a time, with the love of my family behind me, I will beat this . God bless Chris